Backed by clinical evidence
Pixee’s augmented reality technology is backed by a growing body of clinical evidence from independent studies and peer-reviewed publications. Our solutions are continuously evaluated to demonstrate safety, surgical performance, and meaningful benefits for both surgeons and patients.
Key Evidence & Results
- Robotic-level precision6, 9, 11
- No significant difference in the operative time Compared to conventional TKA9
- 0 complications directly related to the usage of Knee+ 2,,6
- PROMs favorable10,11 and comparable with high-performing robotic systems9
Advancing knee surgery
through clinical research
Clinical research is essential to advancing knee surgery and generating the evidence that shapes tomorrow’s standards of care. We welcome collaborations with surgeons, hospitals, and research teams interested in conducting independent studies on Knee+ NexSight. All studies are investigator-initiated and conducted independently, with Pixee Medical providing product information and technical support without influencing study design, data analysis, or publication decisions.
Interested in collaborating? Contact us at marketing@pixee-medical.com to discuss your research project.
Precautions and disclaimers
The clinical studies have been conducted and published independently by investigators. Individual study results reflect the specific methodology, patient population, and clinical setting of each investigation and may not be generalizable to all users or clinical practices.
The information provided is intended for educational and scientific purposes only and should not replace the clinical judgment of healthcare professionals.
[1] Iacono V, Farinelli L, Natali S, Piovan G, Screpis D, Gigante A, et al. The use of augmented reality for limb and component alignment in total knee arthroplasty: systematic review of the literature and clinical pilot study. J Exp Orthop. 2021.
[2]Bennett KM, Griffith A, Sasanelli F, Park I, Talbot S. Augmented Reality Navigation Can Achieve Accurate Coronal Component Alignment During Total Knee Arthroplasty. Cureus. 2023.
[3]Castellarin G, Bori E, Barbieux E, Grandjean VP, Jost G, Innocenti B. Is total knee arthroplasty surgical performance enhanced using augmented reality? A single-center study on 76 consecutive patients. The Journal of Arthroplasty. 2023.
[4]Waitzman J, Kassab S. Pixee knee+ augmented reality assisted navigation for total knee arthroplasty in an ambulatory surgical center. Int J Res Orthop 2024.
[5]Sakellariou E, Alevrogiannis P, Alevrogianni F, Galanis A, Vavourakis M, Karampinas P, Gavriil P, Vlamis J, Alevrogiannis S. Single-center experience with Knee+™ augmented reality navigation system in primary total knee arthroplasty. World J Orthop. 2024.
[6]Lambrechts J, Vansintjan P, Lapierre C, Sinnaeve F, Van Lysebettens W, Van Overschelde. Accuracy of a New Augmented Reality Assisted Technique for Total Knee Arthroplasty: An In Vivo Study. Arthroplast Today. 2024.
[7]Castellarin G, Sisella M, Innocenti B. High accuracy and learning curve improvement of augmented reality in total knee arthroplasty: A single-centre study on 157 patients. J Exp Orthop. 2025.
[8]Duval G, Emery A, Tripon M, Oger R, Dunet J, Maroteau G, Hulet C, Contribution of a new augmented reality system in total knee arthroplasty implantation. An in vivo, prospective, non-comparative study of 60 cases, Orthopaedics & Traumatology: Surgery & Research, 2026.
[9]Panchal S, Barker B, Highcock AJ. Improved alignment and reduced peri-operative blood loss with augmented reality-guided total knee arthroplasty: a single-centre comparative study. J Robot Surg. 2026.
[10]Farner N, Jawanda G, Santiago-Rivera O, Kassab S, Augmented Reality–Assisted vs Manual Total Knee Arthroplasty: Clinical and Perioperative Outcomes in a Consecutive Single-Surgeon Cohort, Arthroplasty Today, 2026.
[11]Dossett HG, Stickels M, Desai R, Kozak A, Shanahan B, Tummala S. Augmented Reality-Guided Individualized Total Knee Arthroplasty: Initial Clinical Implementation and Results. J Am Acad Orthop Surg Glob Res Rev. 2026.